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Amiodarone-induced keratopathy: full-thickness corneal involvement
Mesut Erdurmus1, Yusuf Selcoki, Ramazan Yagci
1Department of Ophthalmology, Fatih University Medical School, Alparslan Turkes Cad No: 57, 06510 Emek, Ankara, Turkey. merdurmus@yahoo.com
Eye & Contact Lens
|March 11, 2008
Summary
This case report details amiodarone-induced keratopathy affecting the entire cornea, including the endothelium. Such severe amiodarone toxicity is rare and warrants attention.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Amiodarone is an antiarrhythmic drug with known ocular side effects.
- Corneal deposits are a common manifestation of amiodarone toxicity.
Observation:
- A 65-year-old male on amiodarone for 6 years presented with blurred vision and halos.
- Examination revealed bilateral, symmetric whorllike corneal epithelial deposits and diffuse endothelial deposits.
- Confocal microscopy confirmed severe endothelial deposition.
Findings:
- The patient exhibited amiodarone-induced keratopathy involving both corneal epithelium and endothelium.
- Endothelial deposition was extensive and diffuse, documented via confocal laser scanning microscopy.
- No other ocular abnormalities related to amiodarone were observed.
Implications:
- This case highlights a rare, severe form of amiodarone-induced keratopathy.
- Confluent endothelial deposition may signal a more significant amiodarone toxicity.
- Ophthalmologists should be aware of this potential severe ocular manifestation.
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