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Related Concept Videos

Criteria for Causality: Bradford Hill Criteria - II01:28

Criteria for Causality: Bradford Hill Criteria - II

The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
Criteria for Causality: Bradford Hill Criteria - I01:30

Criteria for Causality: Bradford Hill Criteria - I

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Cause and Effect01:53

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Spontaneous and Induced Mutations

Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
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Causality in Epidemiology

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William D. Harper, Jr, MS, DC: anything can cause anything.

Joseph C Keating1

  • 1Cleveland Chiropractic College, 6401 Rockhill Road, Kansas City, MO 64131, USA.

The Journal of the Canadian Chiropractic Association
|March 11, 2008
PubMed
Summary

William D. Harper, Jr. was a maverick chiropractor and educator who challenged traditional subluxation theories. His work on aberrant neural irritation and leadership at Texas Chiropractic College left a significant mark on the profession.

Keywords:
HarperTexas Chiropractic Collegechiropractor

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Area of Science:

  • Chiropractic Medicine
  • Medical History
  • Neural Irritation Theory

Background:

  • William D. Harper, Jr. (1912-1997) was an engineer and chiropractor.
  • He served as instructor, writer, and president of Texas Chiropractic College (TCC).
  • Harper pursued alternative explanations for disease beyond traditional subluxation concepts.

Purpose of the Study:

  • To analyze the contributions of William D. Harper, Jr. to chiropractic theory and practice.
  • To examine his role in the development and leadership of Texas Chiropractic College.
  • To understand his critique of chiropractic political factions and his advocacy for the profession.

Main Methods:

  • Historical analysis of Harper's writings, including his textbook "Anything Can Cause Anything."
  • Review of his involvement in the 1965 England case defense of chiropractic.
  • Examination of his leadership tenure at Texas Chiropractic College (1965-1976).

Main Results:

  • Harper proposed aberrant neural irritation as an alternative to the "foot-on-the-hose" subluxation theory.
  • His textbook "Anything Can Cause Anything" disseminated his theories widely.
  • He successfully led Texas Chiropractic College through a critical period of growth and relocation.
  • Harper's defense in the England case was noted for its quality, despite the unfavorable ruling.

Conclusions:

  • William D. Harper, Jr. was a significant, albeit unconventional, figure in chiropractic.
  • His theoretical work and leadership significantly impacted chiropractic education and advocacy.
  • His independent approach and critical analysis of the profession warrant further study.