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Plasma homocysteine level in cardiac syndrome X and its relation with duke treadmill score

Timur Timurkaynak1, Serhat Balcioglu, Ugur Arslan

  • 1Department of Cardiology, Gazi University Medical School, Besevler, Ankara, Turkey. ttimurkaynak@gmail.com

Saudi Medical Journal
|March 11, 2008
PubMed

Insights

Plasma homocysteine levels are elevated in Cardiac Syndrome X (CSX) patients and inversely correlate with exercise capacity, indicating greater ischemia. This finding highlights homocysteine

Area of Science:

  • Cardiology
  • Clinical Biochemistry
  • Vascular Medicine

Background:

  • Cardiac Syndrome X (CSX) is characterized by angina with normal coronary arteries.
  • Endothelial dysfunction and microvascular ischemia are implicated in CSX pathophysiology.
  • Elevated plasma homocysteine is a potential risk factor for cardiovascular diseases.

Purpose of the Study:

  • To determine plasma homocysteine levels in CSX patients.
  • To investigate the relationship between plasma homocysteine and exercise capacity (Duke Treadmill Score) in CSX.

Main Methods:

  • A prospective, controlled study included 79 CSX patients and 30 asymptomatic controls.
  • Plasma homocysteine levels were measured using an immunoassay method.
  • Duke Treadmill Score (DTS) was calculated for CSX patients.

Main Results:

  • Plasma homocysteine levels were significantly higher in CSX patients compared to controls (16.5 vs 12.4 micromol/L).
  • A significant negative correlation was observed between plasma homocysteine levels and DTS in CSX patients (r = -0.506, p < 0.001).

Conclusions:

  • Elevated plasma homocysteine is associated with CSX.
  • Higher homocysteine levels correlate with reduced exercise capacity and potentially greater ischemic burden in CSX patients.
Abstract

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