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Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.

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Related Experiment Video

Updated: Jul 6, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

Increased thrombin generation in persons with echogenic carotid plaques.

Ann-Trude With Notø1, Ellisiv Bøgeberg Mathiesen, Bjarne Østerud

  • 1Center for Atherothrombotic Research in Tromsø, Institute of Clinical Medicine, University of Tromsø, Norway. anntrude@fagmed.uit.no

Thrombosis and Haemostasis
|March 11, 2008
PubMed
Summary

Echogenic carotid plaques, not echolucent ones, are linked to increased thrombin generation, a key factor in blood clotting. This finding is independent of artery narrowing, highlighting plaque appearance as a critical indicator for cerebrovascular events.

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Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli
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Published on: September 25, 2016

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Last Updated: Jul 6, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
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A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

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Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli
13:10

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

Published on: September 25, 2016

Area of Science:

  • Vascular Biology
  • Thrombosis Research
  • Cerebrovascular Disease

Background:

  • Echolucent carotid plaques indicate a higher risk of future ischemic cerebrovascular events (CVE) compared to echogenic plaques.
  • Elevated thrombin generation markers are associated with atherosclerotic plaques and CVE phases.

Purpose of the Study:

  • To investigate the influence of carotid plaque morphology on thrombin generation.
  • To determine if plaque echogenicity or degree of stenosis is more strongly associated with thrombin generation.

Main Methods:

  • 128 individuals with carotid stenosis (>=35% lumen reduction) and 136 controls were studied.
  • Plaque morphology was assessed via ultrasonography.
  • Thrombin generation was measured using thrombin-antithrombin complexes (TAT) and prothrombin fragment 1+2 (F1+2).

Main Results:

  • Individuals with echogenic plaques showed significantly higher TAT and F1+2 levels than those with echolucent plaques and controls.
  • TAT and F1+2 levels increased linearly with plaque echogenicity, irrespective of stenosis degree.
  • Increased thrombin generation correlated with higher plasma factor V levels in echogenic plaque patients.

Conclusions:

  • Plaque echogenicity, not echolucency or stenosis degree, is significantly associated with thrombin generation in carotid stenosis.
  • This suggests plaque appearance is a crucial factor in assessing thrombotic risk.
  • Further research into the mechanisms linking plaque echogenicity and thrombin generation is warranted.