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Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Arterial thrombosis in children.

Victoria E Price1, Anthony K C Chan

  • 1Division of Hematology/Oncology, Department of Pediatrics, IWK Health Centre, Dalhousie University, 5850/5890 University Ave., Halifax, B3K 6R8, Canada. vicky.price@iwk.nshealth.ca

Expert Review of Cardiovascular Therapy
|March 11, 2008
PubMed
Summary

Pediatric arterial thromboembolism is an uncommon but increasing complication of advanced medical care. This review summarizes current knowledge on the causes, diagnosis, and treatment of non-central nervous system arterial clots in children.

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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
06:38

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Published on: December 19, 2025

Area of Science:

  • Pediatric critical care medicine
  • Pediatric hematology
  • Vascular medicine

Background:

  • Arterial thromboembolism (ATE) is a rare but serious condition in children.
  • Advances in pediatric tertiary care have led to increased survival from critical illnesses, paradoxically increasing the incidence of previously rare complications like ATE.
  • The underlying mechanisms of thrombosis in children differ significantly from adults.

Purpose of the Study:

  • To review and summarize current data on the etiology, diagnosis, and management of arterial thrombosis outside the central nervous system (CNS) in pediatric patients.
  • To highlight the unique aspects of pediatric arterial thrombosis compared to adult populations.
  • To provide a comprehensive overview for clinicians managing this condition.

Main Methods:

  • Systematic review of existing literature on pediatric arterial thromboembolism.
  • Analysis of data concerning causes, diagnostic methods, and therapeutic strategies.
  • Focus on non-CNS ATE in children.

Main Results:

  • Etiology of pediatric ATE is multifactorial, often related to underlying critical illnesses and their treatments.
  • Diagnostic approaches require specialized pediatric considerations.
  • Management strategies are evolving and necessitate a tailored pediatric approach.

Conclusions:

  • Arterial thromboembolism in children requires a distinct diagnostic and therapeutic strategy due to unique pathophysiology.
  • Effective management hinges on understanding pediatric-specific risk factors and treatment responses.
  • Further research is needed to optimize outcomes for children experiencing ATE.