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Related Concept Videos

Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Related Experiment Video

Updated: Jul 6, 2026

Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models
10:09

Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models

Published on: October 9, 2014

External fixators as an adjunct to wound healing.

Mark W Clemens1, Pranay Parikh, Melanie M Hall

  • 1Division of Wound Healing, Department of Plastic Surgery, Georgetown University Medical Center, 3800 Reservoir Road NW, Washington, DC 20007, USA.

Foot and Ankle Clinics
|March 11, 2008
PubMed
Summary

External fixators help complex foot and ankle wound healing by temporarily immobilizing joints. This prevents shear forces and pressure, improving outcomes for reconstructive surgery patients.

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Area of Science:

  • Orthopedic Surgery
  • Wound Healing
  • Reconstructive Surgery

Background:

  • Complex foot and ankle wounds pose significant challenges for reconstructive surgeons.
  • Effective wound closure is crucial for protecting underlying structures and promoting healing.
  • Common surgical options include secondary intention, local flaps, skin grafts, and tissue transfers.

Purpose of the Study:

  • To highlight the role of external fixators as an adjunct in managing complex foot and ankle wounds.
  • To emphasize the benefits of joint offloading and immobilization in preventing wound healing complications.

Main Methods:

  • Review of surgical strategies for complex foot and ankle wounds.
  • Discussion of complications arising from postoperative shear forces and pressure.
  • Evaluation of external fixators as a method for joint immobilization and offloading.

Main Results:

  • Surgical closure methods can fail due to postoperative shear forces and pressure.
  • External fixators provide temporary joint offloading or immobilization.
  • This adjunct can create a stable environment conducive to wound healing.

Conclusions:

  • External fixators are valuable tools for reconstructive surgeons treating complex foot and ankle wounds.
  • Proper patient selection is key to maximizing the benefits of external fixator use.
  • This technique aids in preventing complications and improving overall treatment success.