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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
The structure of protein evolution and the evolution of protein structure
1Division of Mathematical Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. richard.goldstein@nimr.mrc.ac.uk
Abstract:
The observed distribution of protein structures can give us important clues about the underlying evolutionary process, imposing important constraints on possible models. The availability of results from an increasing number of genome projects has made the development of these models an active area of research. Models explaining the observed distribution of structures have focused on the inherent functional capabilities and structural properties of different folds and on the evolutionary dynamics. Increasingly, these elements are being combined.
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