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Related Experiment Video

Updated: Jul 6, 2026

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation

Published on: August 13, 2015

Sensitization does not develop in utero.

Klaus Bønnelykke¹, Christian Bressen Pipper, Hans Bisgaard

¹Danish Pediatric Asthma Center, Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark. kb@copsac.dk

The Journal of Allergy and Clinical Immunology

|March 11, 2008

Summary

This summary is machine-generated.

Allergen-specific immunoglobulin E (IgE) in cord blood does not indicate intrauterine sensitization. This finding suggests maternal IgE transfer to the fetus, not fetal sensitization, is responsible for IgE presence at birth.

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Last Updated: Jul 6, 2026

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation

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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Published on: March 25, 2016

Area of Science:

Immunology
Allergy Research
Perinatal Medicine

Background:

Intrauterine sensitization is hypothesized to contribute to childhood atopic diseases.
Current guidelines suggest allergen avoidance during pregnancy to prevent atopic conditions.

Purpose of the Study:

To determine if allergen-specific IgE in cord blood correlates with infant sensitization.
To investigate the origin of allergen-specific IgE detected in cord blood.

Main Methods:

Analysis of inhalant and food allergen-specific IgE in cord blood, infant blood (6 months), and parental blood.
Measurement of cord blood IgA to assess maternal blood contamination.
Comparison of IgE specificity, levels, and total IgE ratios between cord and maternal blood.

Main Results:

Allergen-specific IgE was found in 14% of cord blood samples, mainly against inhalant allergens.
No corresponding specific IgE was detected in infant blood at 6 months of age.
Cord blood specific IgE mirrored maternal blood IgE in specificity and levels, with a correlation between cord blood IgE and IgA.

Conclusions:

Allergen-specific IgE in cord blood does not indicate intrauterine sensitization.
The presence of specific IgE in cord blood likely results from passive transfer of maternal IgE to the fetus.
Findings challenge the rationale for prenatal allergen avoidance based on cord blood IgE levels.