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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

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Related Experiment Video

Updated: Jul 6, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

[Juvenile osteoporosis].

D Delalande1, C Jung, I Labedan

  • 1Service de réanimation, hôpital Robert-Debré, 48 boulevard Sérurier, Paris, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|March 11, 2008
PubMed
Summary
This summary is machine-generated.

Juvenile osteoporosis results from bone turnover disorders, impacting bone density. Prevention through diet, vitamin D, calcium, and exercise is key, while treatments like bisphosphonates require caution in children.

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Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Related Experiment Videos

Last Updated: Jul 6, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Area of Science:

  • Pediatrics
  • Endocrinology
  • Bone Biology

Background:

  • Osteoporosis involves accelerated bone destruction and matrix rarefaction, regulated by the RANK-L/RANK/OPG system.
  • Juvenile osteoporosis has primary or secondary causes, including genetic factors, chronic inflammation, and prolonged steroid use.
  • Early diagnosis is challenging, often occurring after complications arise.

Purpose of the Study:

  • To review the pathophysiology, diagnosis, and management of juvenile osteoporosis.
  • To highlight the role of the RANK-L/RANK/OPG system in bone remodeling.
  • To discuss current and potential therapeutic strategies for pediatric osteoporosis.

Main Methods:

  • Literature review of osteoporosis in children and adolescents.
  • Analysis of diagnostic tools like osteodensitometry and their limitations.
  • Evaluation of preventive measures and current treatment options, including bisphosphonates.

Main Results:

  • Osteodensitometry is a sensitive tool for pediatric bone density measurement but has limitations related to patient variability.
  • Preventive strategies include adequate nutrition, vitamin D and calcium supplementation, and physical activity.
  • Bisphosphonates are used for symptomatic cases, but long-term safety in children is unknown; newer adult treatments lack pediatric data.

Conclusions:

  • Effective management of juvenile osteoporosis requires a focus on prevention and cautious application of existing treatments.
  • Further research is needed on the long-term effects of osteoporosis treatments in the pediatric population.
  • Understanding the RANK-L/RANK/OPG system is crucial for developing targeted therapies.