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Updated: Jul 6, 2026
Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
Published on: September 25, 2011
Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection
Jaemoon Yang1, Eun-Kyung Lim, Hong Jae Lee
1Department of Chemical Engineering, Yonsei University, 134 Shinchon-dong Seodaemoon-ku, Seoul, Republic of Korea.
Abstract:
Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe(2)O(4) magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.
