Related Experiment Video
Updated: Jul 6, 2026

Generation and Single-Cell Transcriptomic Analysis of Hepatocellular Carcinoma Organoids following Drug Treatment
Published on: May 26, 2026
Hepatic gene expression and prediction of therapy response in chronic hepatitis C patients
Nazia Selzner1, Limin Chen, Ivan Borozan
1Multiorgan Transplant Program, University Health Network, University of Toronto, Toronto General Hospital, 585 University Avenue, Toronto, Ontario, Canada.
Abstract:
Chronic hepatitis C (HCV) infection remains a major health problem worldwide. The current standard of care is a combination of pegylated interferon-alpha and ribavirin. Considering the length of antiviral therapy, as well as its side effects and costs, accurate prediction of treatment response prior to initiation of treatment is critical. In addition to viral, demographic and environmental factors, host genetic diversity is believed to contribute to the spectrum of clinical outcomes of chronic HCV. The development of high-throughput technologies provides opportunities to define patterns of gene expression that are associated with certain disease outcomes and/or response to therapy. This article reviews genomics-based predictors of pre-treatment response to antiviral therapy.
Related Concept Videos
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Pharmacogenetics of Phase I Enzymes: Cytochrome P450 Isozymes
Cell Specific Gene Expression
Hepatic Drug Excretion: Influencing Factors
Pharmacogenomics: Identification of New Drug Targets

