Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Complex I drives glutamine-dependent TCA cycle to support viability of MYC<sup>high</sup> breast cancer cells.

Cell reports·2026
Same author

Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition.

Cell reports·2026
Same author

Editorial Expression of Concern: Creation of human tumour cells with defined genetic elements.

Nature·2026
Same author

CREB5 regulates stem cell-like transcriptional programs to enhance tumor progression in prostate cancer.

Oncotarget·2026
Same author

SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity.

Nature communications·2026
Same author

Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network.

Molecular cell·2026

Related Experiment Video

Updated: Jul 6, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

Multiple pathways regulated by the tumor suppressor PP2A in transformation.

Jukka Westermarck1, William C Hahn

  • 1Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland.

Trends in Molecular Medicine
|March 11, 2008
PubMed
Summary

Protein phosphatase 2A (PP2A) inactivation contributes to cancer by altering cell signaling. This review covers PP2A

Related Experiment Videos

Last Updated: Jul 6, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

Area of Science:

  • Molecular biology
  • Cellular signaling
  • Cancer research

Background:

  • Reversible protein phosphorylation is crucial for intracellular signaling.
  • Dysregulation of phosphorylation mechanisms contributes to cancer initiation and progression.
  • While oncogenic kinases are well-studied, protein phosphatases also play significant roles in malignancy.

Purpose of the Study:

  • To review the role of Protein phosphatase 2A (PP2A) in cancer pathogenesis.
  • To elucidate how PP2A regulates mitogenic signaling pathways in cancer.
  • To discuss the modulation of PP2A activity in human cancers.

Main Methods:

  • Literature review of recent scientific progress.
  • Analysis of PP2A's role in regulating phosphorylation events.
  • Examination of PP2A inactivation mechanisms in cancer.

Main Results:

  • PP2A is the primary serine-threonine phosphatase in mammalian cells.
  • Inactivation of PP2A, through viral oncoproteins, mutations, or inhibitors, promotes cell transformation.
  • PP2A regulates key mitogenic signaling pathways implicated in cancer.

Conclusions:

  • PP2A inactivation is a significant factor in cancer development.
  • Understanding PP2A's regulatory mechanisms in cancer is critical for therapeutic strategies.
  • Further research into PP2A modulation in human cancers is warranted.