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Published on: December 9, 2016
[Long-term results following multidisciplinary treatment of localized Ewing's sarcoma in children and adolescents]
Christian Ullmann1, Jörn-Dirk Beck, Wolfgang Holter
1Strahlenklinik, Universitätsklinikum Erlangen, Erlangen.
Purpose:
To identify results and prognostic factors on long-term survival and local control following treatment of localized Ewing's sarcoma.
Patients And Methods:
Between 1979 and 2004, a total of 60 children and young adults with Ewing's sarcoma were treated. Patients with distant metastases at presentation (n = 6) and recurrent cases (n = 2) were excluded from this analysis. Patients were exclusively treated within ongoing national and international protocols CESS-81, CESS-86, EICESS-92, EURO-EWING-99. All patients received local irradiation with a total dose of 45-60 Gy; in addition, 41 (79%) of the patients had local surgical procedures, 27 (52%) of them with clear margins.
Results:
Overall survival rates at 5 and 10 years were 56% and 45%, respectively. Patients
Conclusion:
Radiotherapy with and without surgery of Ewing's sarcoma is a highly effective local treatment option. It seems preferable to mutilating surgery.
