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Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System
Published on: December 10, 2021
Sexuality in Huntington's disease
Eva Z Schmidt1, Raphael M Bonelli
1Department of Psychiatry, Medical University of Graz, Graz, Austria.
Wiener Medizinische Wochenschrift (1946)
|March 12, 2008
Summary
Sexuality is significantly impacted in Huntington's disease (HD), with most patients experiencing sexual problems. More research is needed to understand the causes and treatments for sexual dysfunction in HD.
Area of Science:
- Neuroscience
- Psychiatry
- Human Sexuality
Background:
- Sexuality and partnership are crucial for quality of life in chronic disorders.
- Limited research exists on sexuality in Huntington's disease (HD).
Purpose of the Study:
- To review the current understanding of sexual dysfunction in Huntington's disease.
- To identify knowledge gaps and suggest future research directions.
Main Methods:
- Literature review of studies on sexuality in Huntington's disease.
- Analysis of reported sexual problems, including hypoactive sexual disorder, increased sexual interest, and paraphilia.
Main Results:
- High prevalence of sexual problems reported: up to 85% of men and 75% of women with HD.
- Observed symptoms include hypoactive sexual disorder, increased sexual interest, and paraphilia.
- The cause of sexual dysfunction (neurological vs. psychosocial) remains unclear.
Conclusions:
- Sexual dysfunction is common in Huntington's disease, but its underlying causes require further investigation.
- Future research should examine asymptomatic patients, include partners, and explore links with psychiatric symptoms.
- Evidence-based treatment guidelines for sexual dysfunction in HD are lacking and urgently needed.
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