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Published on: February 4, 2014
Ethnic neutropenia and clozapine
1Cumberland Psychiatric Hospital, University of Sydney, Sydney, New South Wales, Australia. abray@med.usyd.edu.au
Objectives:
The aim of the present paper was to examine the concept of benign ethnic neutropenia and to consider the implications of ethnicity in the current clozapine regulatory system.
Method:
The case of a young Palestinian man who lost access to clozapine due to a fall in his neutrophil count, is presented herein, and a brief review of ethnic variations in neutrophil levels is given.
Results:
This patient's clozapine was ceased, with unfortunate consequences, despite his having normal immune function.
Conclusion:
By using normative haematological data established in white populations, the Australian clozapine regulatory system places some non-white patients at a considerable disadvantage.
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