Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 6, 2026

Cell Type-specific Gene Expression Profiling in the Mouse Liver
10:06

Cell Type-specific Gene Expression Profiling in the Mouse Liver

Published on: September 17, 2019

RNA expression microarray analysis in mouse prospermatogonia: identification of candidate epigenetic modifiers.

Christophe Lefèvre1, Jeffrey R Mann

  • 1Department of Zoology, The University of Melbourne, Victoria, Australia.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|March 12, 2008
PubMed
Summary

Mammalian germ line cells undergo extensive DNA methylation changes for epigenetic reprogramming. Researchers identified key genes involved in these dynamic DNA methylation processes in prospermatogonia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of gene-alcohol interaction loci influencing blood pressure in 1.1 million individuals from multiple populations.

Research square·2026
Same author

Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals.

medRxiv : the preprint server for health sciences·2026
Same author

Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations.

HGG advances·2026
Same author

Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants.

Atherosclerosis·2025
Same author

A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations.

Molecular psychiatry·2025
Same author

A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations.

Research square·2025

Area of Science:

  • Epigenetics
  • Developmental Biology
  • Genomics

Background:

  • Mammalian development involves dynamic genome-wide DNA methylation changes.
  • Epigenetic reprogramming is crucial for major differentiation events, particularly in the germ line.
  • Two major phases of DNA demethylation and remethylation occur during mammalian development and germ cell formation.

Purpose of the Study:

  • To investigate the molecular mechanisms driving DNA methylation dynamics during epigenetic reprogramming.
  • To identify genes involved in epigenetic modification in fetal prospermatogonia.
  • To understand the pathways underlying germ line epigenetic reprogramming.

Main Methods:

  • RNA expression microarray analysis was performed.
  • Fetal prospermatogonia undergoing de novo DNA remethylation were analyzed.

More Related Videos

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

Related Experiment Videos

Last Updated: Jul 6, 2026

Cell Type-specific Gene Expression Profiling in the Mouse Liver
10:06

Cell Type-specific Gene Expression Profiling in the Mouse Liver

Published on: September 17, 2019

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

  • Gene expression profiles were examined to identify key genes.

    • Main Results:

    • A number of highly and specifically expressed genes were identified in fetal prospermatogonia.
    • These identified genes are potentially crucial for epigenetic changes.
    • The study provides a resource for discovering molecular pathways in germ line epigenetic reprogramming.

    Conclusions:

    • The identified genes may play significant roles in regulating DNA methylation dynamics.
    • Understanding these genes is vital for comprehending germ line epigenetic reprogramming.
    • This research offers insights into the molecular basis of epigenetic resetting in mammalian germ cells.