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Updated: Jul 6, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
Atomic structure of a short alpha-helix stabilized by a main chain hydrogen-bond surrogate
Jie Liu1, Deyun Wang, Qi Zheng
1Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.
Abstract:
Herein we report the 1.15 A X-ray crystal structure of a short alpha-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived alpha-helix truly resembles the structure of canonical alpha-helices and provides unequivocal support for our helix nucleation strategy.
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