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Updated: Jul 6, 2026
Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
The management of oral mucous membrane pemphigoid with dapsone and topical corticosteroid
1Department of Oral Medicine, Faculty of Dentistry, Ahwaz University of Medical Sciences, Ahwaz, Iran. drarashazizi@yahoo.com
Statement Of Problem:
Mucous membrane pemphigoid (MMP) is a chronic autoimmune subepithelial disease that primarily affects the mucous membranes of patients over the age of 50 years, resulting in mucosal ulceration and subsequent scarring.
Purpose:
The purpose of this study was to investigate the efficacy of dapsone in combination with topical corticosteroids to treat the oral lesions of MMP.
Materials And Methods:
Twenty-two patients who had been diagnosed with MMP were selected. The oral features were graded according to severity of disease from 1 to 3. Each patient was assigned to one of four groups according to his or her response to therapy.
Results:
Five patients with mild to moderate disease were treated with topical corticosteroids alone for the duration of the study; 15 patients with moderate to severe disease were treated by topical corticosteroid with dapsone therapy. All of 15 patients had significant benefits.
Conclusions:
The use of dapsone in combination with topical corticosteroids is one of the most useful methods for the treatment of MMP.
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