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Conducting Respiratory Oscillometry in an Outpatient Setting
Published on: April 8, 2022
Utility of impulse oscillometry in young children with asthma
Tae Won Song1, Kyung Won Kim, Eun Soo Kim
1Division of Allergy and Respiratory Medicine, Department of Pediatrics, Ilsan Paik Hospital, Inje University College of Medicine, Goyang-si, Korea.
Insights
Impulse Oscillometry (IOS) effectively measures lung function in young asthmatic children, outperforming spirometry. IOS provides objective outcomes for early asthma diagnosis and intervention monitoring.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Allergy and Immunology
Background:
- Impulse Oscillometry (IOS) is a non-invasive lung function test suitable for young children.
- Asthma diagnosis in preschool-aged children presents challenges with conventional spirometry.
- Early detection and monitoring are crucial for managing pediatric asthma.
Purpose of the Study:
- To evaluate the utility of Impulse Oscillometry (IOS) compared to spirometry for assessing lung function in asthmatic Korean children aged 3-6 years.
- To determine if IOS can differentiate asthmatic children from healthy controls.
- To assess the role of IOS in evaluating bronchodilator response in pediatric asthma.
Main Methods:
- A comparative study involving 77 asthmatic children and 55 control subjects aged 3-6 years.
- Lung function was assessed using both Impulse Oscillometry (IOS) and spirometry before and after bronchodilator administration.
- Serum IgE, eosinophil counts, and specific IgE levels were measured.
Main Results:
- Asthmatic children showed significant differences in baseline resistance and IOS-assessed bronchodilator response compared to controls.
- Conventional spirometry did not yield statistically significant findings between groups.
- IOS demonstrated significant differences in bronchodilator response in both atopic and non-atopic asthmatic children.
Conclusions:
- Impulse Oscillometry (IOS) is a valuable tool for diagnosing early-stage asthma in young children.
- IOS serves as a helpful objective measure for evaluating the effectiveness of early interventions in pediatric asthma.
- IOS offers a more sensitive assessment of lung function in this age group compared to spirometry.
Abstract:
Impulse Oscillometry (IOS) was developed as a tool to measure lung function, and as it only requires passive cooperation, it has been successfully used in younger children. The aim of this study was to assess the utility of IOS compared to conventional spirometry for lung function measures in asthmatic Korean children aged 3 to 6 yrs. Total serum IgE levels, total eosinophil counts, and specific IgE levels were measured in 77 children with asthma and 55 control subjects. IOS and spirometry were performed in the children before and after bronchodilator administration. Asthmatic children significantly differed from control subjects in baseline resistance at 10 Hz and in their IOS-assessed bronchodilator responses through a Delta resistance at 5 Hz (mean, -27.4% vs. -13.1%; p = 0.002), 10 Hz (mean, -20.4% vs. -11.5%; p = 0.012), 20 Hz (mean, -16.4% vs. -9.4%; p = 0.016), and 35 Hz (mean, -17.2% vs. -10.2%; p = 0.020). Conventional spirometry did not show statistically significant findings. Asthmatic children significantly differed from control subjects in IOS-assessed bronchodilator response through a Delta resistance at 5 Hz, both in atopic children and in non-atopic children. For atopic children, atopic asthmatic children (n = 58) also significantly differed from atopic controls (n = 30) in baseline resistance at 10 Hz, 20 Hz, 35 Hz and impedance and in IOS-assessed bronchodilator responses through a Delta resistance at 10 Hz and 35 Hz. There were some significant correlations between bronchodilator responses of spirometric parameters and IOS parameters. IOS is useful diagnostic tool in early asthma development and might be a helpful objective outcome measure of early interventions.
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