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Updated: Jul 6, 2026
09:30
Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
Published on: May 24, 2019
Exosome function: from tumor immunology to pathogen biology
Jeffrey S Schorey1, Sanchita Bhatnagar
1Center for Global Health and Infectious Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. schorey.1@nd.edu
Traffic (Copenhagen, Denmark)
|March 12, 2008
Summary
Exosomes, or bioactive vesicles, facilitate intercellular communication and play roles in disease. This review explores exosome biogenesis, function, and potential as biomarkers and vaccine candidates.
Area of Science:
- Cell Biology
- Immunology
- Biochemistry
Background:
- Exosomes are bioactive vesicles mediating intercellular communication.
- Their biogenesis involves multivesicular bodies fusing with the plasma membrane.
- Exosomes are released by various cell types, but their precise functions are still under investigation.
Purpose of the Study:
- To review exosome biogenesis and composition.
- To focus on novel insights into exosome functions.
- To discuss the potential of exosomes as disease biomarkers and vaccine candidates.
Main Methods:
- Literature review of recent studies on exosomes.
- Analysis of exosome biogenesis and release mechanisms.
- Examination of exosome roles in intercellular communication, disease, and immunity.
Main Results:
- Exosomes are implicated in intercellular communication and can spread infectious agents.
- Exosomes from infected cells contain microbial components, aiding antigen presentation and macrophage activation.
- Exosomes may be involved in immune surveillance.
Conclusions:
- Exosomes have diverse functions beyond tumor antigen presentation.
- Exosomes show promise as diagnostic biomarkers for various diseases.
- Exosomes represent potential candidates for novel vaccine development.
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02:17The Tumor Microenvironment
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02:17The Tumor Microenvironment
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