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Risk factors associated with surgical site infection and the development of short-term complications in macaques
M L Graham1, E F Rieke, M Wijkstrom
1Department of Surgery, University of Minnesota, Minneapolis, MN, USA. graha066@umn.edu
Background:
Risk factors associated with surgical site infection (SSI) and the development of short-term complications in macaques undergoing vascular access port (VAP) placement are evaluated in this study.
Methods:
Records from 80 macaques with VAPs were retrospectively reviewed. Logistic regression was used to identify factors associated with short-term post-operative complications.
Results:
The primary outcome was SSI, which occurred in 21.6% (52.6% in the first 12 months vs. 13% thereafter) of procedures. SSI was associated with major secondary complications including VAP removal (11.4%), wound dehiscence (5.7%), and mechanical catheter occlusion (5.7%). In multivariate modeling, only surgical program progress was a statistically significant predictor of SSI, while animal compliance had a slightly protective effect.
Conclusions:
Vascular access ports have a moderate risk of complications, provided the surgical program optimizes best practices. Under complex experimental conditions, VAPs represent an important refinement, both improving animals' overall well-being and environment and reducing stress.
Insights
Vascular access ports (VAPs) in macaques have a moderate risk of surgical site infections (SSIs), influenced by surgical program progress. Optimizing best practices can mitigate these risks and improve animal welfare.
Area of Science:
- Veterinary Surgery
- Primate Research
- Animal Models
Background:
- Surgical site infections (SSIs) and short-term complications are potential risks in macaques undergoing vascular access port (VAP) placement.
- Understanding risk factors is crucial for improving outcomes in preclinical research settings.
Purpose of the Study:
- To evaluate risk factors for surgical site infection (SSI) in macaques with vascular access ports (VAPs).
- To identify factors associated with short-term post-operative complications following VAP placement.
Main Methods:
- Retrospective review of records from 80 macaques with VAPs.
- Logistic regression analysis to determine predictors of short-term post-operative complications.
Main Results:
- Surgical site infection (SSI) occurred in 21.6% of procedures, with a higher incidence in the first 12 months (52.6%) compared to later (13%).
- SSIs were linked to VAP removal (11.4%), wound dehiscence (5.7%), and catheter occlusion (5.7%).
- Surgical program progress was a significant predictor of SSI; animal compliance showed a protective effect.
Conclusions:
- Vascular access ports (VAPs) present a moderate risk of complications, emphasizing the need for optimized surgical best practices.
- VAPs are valuable tools in complex experimental settings, enhancing animal well-being and reducing stress.
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