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Updated: Jul 6, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

[Etiological analysis on bacterial endophthalmitis].

Zhe Ren¹, Zhi-qun Wang, Ran Li

¹Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Capital University of Medical Sciences, Beijing 100005, China.

[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology

|March 12, 2008

Summary

Bacterial endophthalmitis involves diverse organisms, with decreasing antibiotic susceptibility over time. Combination therapy is recommended for effective empiric treatment of this serious eye infection.

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Area of Science:

Ophthalmology
Microbiology
Infectious Diseases

Context:

Bacterial endophthalmitis is a severe intraocular infection.
Understanding the causative organisms and their antibiotic resistance patterns is crucial for effective treatment.
This study analyzes microbiological data from suspected endophthalmitis cases over an eight-year period.

Purpose:

To identify the spectrum of bacteria causing endophthalmitis.
To determine the in vitro antibiotic susceptibility of these isolates to common ocular antibiotics.
To assess trends in antibiotic resistance over time.

Summary:

A retrospective analysis of 728 intraocular specimens identified 168 bacterial isolates.
Staphylococcus epidermidis, Staphylococcus aureus, and Pseudomonas aeruginosa were the most common pathogens.
Antibiotic susceptibility testing revealed varying efficacy, with decreasing susceptibility observed in later years.
No single antibiotic demonstrated complete coverage for all isolated organisms.

Impact:

Highlights the complex etiology of bacterial endophthalmitis.
Underscores the challenge posed by emerging antibiotic resistance in ocular infections.
Supports the recommendation for combination therapy as initial empiric treatment for suspected bacterial endophthalmitis.