Related Experiment Video

Updated: Jul 6, 2026

Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation
10:04

Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation

Published on: January 12, 2016

[Stroke in HIV-infected patients]

Ireneia Lino1, António Sousa, José Correia

  • 1Serviço de Medicina 2, Hospital do Espírito Santo, Evora.

Acta Medica Portuguesa
|March 12, 2008
PubMed

Insights

Human immunodeficiency virus (HIV) infection is now a chronic condition due to new treatments. This review examines the increased risk of stroke in HIV patients, especially those on highly active antiretroviral therapy (HAART).

Area of Science:

  • Neurology
  • Infectious Diseases
  • Cardiology

Context:

  • The management of human immunodeficiency virus (HIV) infection has evolved, shifting it towards a chronic disease model.
  • Historically, stroke in HIV patients was attributed to opportunistic infections or tumors.
  • Emerging evidence suggests vascular diseases, including stroke, pose a significant threat to patients undergoing highly active antiretroviral therapy (HAART).

Purpose:

  • To review the complex association between HIV infection and stroke.
  • To analyze the evolving risk factors for stroke in the context of modern HIV treatment regimens.
  • To highlight the impact of HAART on cerebrovascular disease in HIV-positive individuals.

Summary:

  • This paper synthesizes current knowledge on the relationship between HIV and stroke.
  • It investigates how advancements in HIV treatment, particularly HAART, may influence stroke risk.
  • The review analyzes the changing landscape of HIV disease spectrum and its implications for vascular health.

Impact:

  • Provides a comprehensive overview of HIV-associated stroke, crucial for clinicians managing these patients.
  • Highlights the need for increased vigilance regarding cardiovascular risk in HIV-positive individuals on HAART.
  • Informs future research directions into the mechanisms and prevention of stroke in the context of HIV infection.

More Related Videos

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Related Concept Videos

Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...