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10:04
Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation
Published on: January 12, 2016
[Stroke in HIV-infected patients].
Ireneia Lino1, António Sousa, José Correia
1Serviço de Medicina 2, Hospital do Espírito Santo, Evora.
Acta Medica Portuguesa
|March 12, 2008
Summary
Human immunodeficiency virus (HIV) infection is now a chronic condition due to new treatments. This review examines the increased risk of stroke in HIV patients, especially those on highly active antiretroviral therapy (HAART).
Area of Science:
- Neurology
- Infectious Diseases
- Cardiology
Context:
- The management of human immunodeficiency virus (HIV) infection has evolved, shifting it towards a chronic disease model.
- Historically, stroke in HIV patients was attributed to opportunistic infections or tumors.
- Emerging evidence suggests vascular diseases, including stroke, pose a significant threat to patients undergoing highly active antiretroviral therapy (HAART).
Purpose:
- To review the complex association between HIV infection and stroke.
- To analyze the evolving risk factors for stroke in the context of modern HIV treatment regimens.
- To highlight the impact of HAART on cerebrovascular disease in HIV-positive individuals.
Summary:
- This paper synthesizes current knowledge on the relationship between HIV and stroke.
- It investigates how advancements in HIV treatment, particularly HAART, may influence stroke risk.
- The review analyzes the changing landscape of HIV disease spectrum and its implications for vascular health.
Impact:
- Provides a comprehensive overview of HIV-associated stroke, crucial for clinicians managing these patients.
- Highlights the need for increased vigilance regarding cardiovascular risk in HIV-positive individuals on HAART.
- Informs future research directions into the mechanisms and prevention of stroke in the context of HIV infection.
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