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Yorkie and Scalloped: partners in growth activation

Jennifer L Bandura1, Bruce A Edgar

  • 1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Developmental Cell
|March 12, 2008
PubMed

Insights

The Hippo signaling pathway controls organ size by inhibiting Yorkie/YAP. Scalloped/TEAD acts as the key transcription factor partner for Yorkie/YAP in this growth-limiting pathway.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cell Signaling

Background:

  • The Hippo (Hpo) signaling pathway is a crucial regulator of organ size across diverse species, including mammals.
  • This pathway functions by inhibiting the transcriptional coactivator Yorkie (Yki) or YAP (Yes-associated protein).

Purpose of the Study:

  • To identify the downstream transcriptional targets of the Hippo signaling pathway.
  • To elucidate the mechanism by which Hippo signaling controls organ growth through its interaction with Yorkie/YAP.

Main Methods:

  • Utilized genetic screens in Drosophila to identify interacting partners of Yki.
  • Performed molecular assays to confirm protein-protein interactions and transcriptional activity.

Main Results:

  • Identified Scalloped (Sd), a TEAD/TEF transcription factor, as the first known direct binding partner of Yki.
  • Demonstrated that Scalloped/TEAD is a critical downstream effector of Hippo signaling, mediating the suppression of Yki/YAP activity.

Conclusions:

  • Scalloped/TEAD is a key transcription factor that partners with Yki/YAP to regulate organ growth.
  • This finding provides a fundamental insight into the molecular mechanisms of the Hippo signaling pathway and its role in developmental processes.

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