L1 cell adhesion molecule (L1CAM) as a pathogenetic factor in endometriosis
1Department of Obstetrics and Gynecology, University of Schleswig-Holstein, Ratzeburgerallee 160, 23538 Luebeck, Germany.
Human Reproduction (Oxford, England)
|March 12, 2008
Summary
L1 cell adhesion molecule (L1CAM) is overexpressed in endometriosis, particularly atypical forms. This suggests L1CAM may drive endometriosis progression by increasing nerve growth and disease severity.
Area of Science:
- Gynecology
- Oncology
- Molecular Biology
Background:
- Endometriosis is a prevalent, progressive disease.
- Increased risk of ovarian cancer is linked to endometriosis, especially atypical forms.
- L1 cell adhesion molecule (L1CAM) overexpression in cancers correlates with poor prognosis.
Purpose of the Study:
- To investigate L1CAM expression in endometriosis.
- To determine the role of L1CAM in endometriosis development and progression.
Main Methods:
- Analysis of L1CAM mRNA and protein levels in endometriosis samples (n=79) versus controls (n=37).
- Quantitative RT-PCR and immunohistochemical staining.
- Assessment of soluble L1 effects on neurite outgrowth in a chicken ganglion assay.
Main Results:
- L1CAM mRNA and protein were expressed in endometriosis tissues and cell lines.
- Significantly higher L1CAM levels were found in the epithelial compartment of patients with endometriosis (P = 0.0126).
- L1CAM staining was positive in 48% of ovarian endometriotic lesions, predominantly in atypical cases (13/15).
- Soluble L1 stimulated neurite outgrowth.
Conclusions:
- L1CAM may promote endometriosis by enhancing enervation and disease aggravation.
- L1CAM expression is elevated in atypical endometriosis compared to normal endometriosis.
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