Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T helper cell-dependent B cell activation.

R J Noelle1, E C Snow

  • 1Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03756.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|October 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.

Scientific reports·2020
Same author

VISTA: Coming of age as a multi-lineage immune checkpoint.

Clinical and experimental immunology·2020
Same author

Blocking the VISTA pathway enhances disease progression in (NZB × NZW) F1 female mice.

Lupus·2017
Same author

Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.

Scientific reports·2015
Same author

Mast cell protease 6 is required for allograft tolerance.

Transplantation proceedings·2010
Same author

The Mortality from Phthisis: A Statistical Investigation having bearing upon the Question of Personal Communicability.

Proceedings of the Royal Society of Medicine·2009
Same journal

Sinomenine Regulates the TRIM32/IRF1/TRAF6 Axis to Inhibit Pyroptosis in Atopic Dermatitis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Urolithin A Mitigates Renal Fibrosis by Promoting Fatty Acid Oxidation Through Orchestrating β-Catenin Signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

MiR-124 Inhibits Lipid Deposition in Mouse Liver by Targeting the Trib3/Hnf4α Pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

TCN2 Drives Psoriasis-Like Inflammation and Keratinocyte Hyperproliferation, Correlating With IL-1β and STAT3 Activation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

The Synthetic Melanocortin Agonist NDP-MSH Ameliorates THSD7A-Associated Membranous Nephropathy in an Active Immunization Mouse Model.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Brain-Derived Neurotrophic Factor and Associated Signaling in Kidney Diseases.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
See all related articles

B lymphocytes activate upon antigen binding to their membrane immunoglobulin receptors. Subsequent interactions with helper T cells drive B cell growth and differentiation into antibody-producing cells.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • B lymphocytes are quiescent until stimulated by environmental signals.
  • Antigen binding to membrane immunoglobulin (mIg) initiates B cell activation.
  • Antigen fragments presented with MHC class II molecules are crucial for T cell recognition.

Purpose of the Study:

  • To review the sequential events leading to B lymphocyte activation and antibody production.
  • To elucidate the role of T cell interactions in B cell differentiation.

Main Methods:

  • This is a review article, synthesizing existing research.
  • Focuses on the signaling pathways and cellular interactions involved in B cell activation.

Main Results:

Related Experiment Videos

  • Antigen binding triggers B cells to internalize and process antigen.
  • B cells present processed antigen fragments via MHC class II molecules.
  • CD4+ helper T cells recognize the antigen-MHC complex, forming conjugates with B cells.
  • B cell and T cell conjugate formation leads to mutual signaling, promoting growth and differentiation.

Conclusions:

  • The interaction between B cells and helper T cells is essential for B cell differentiation into antibody-producing plasma cells.
  • Understanding these signaling cascades provides insight into adaptive immune responses.