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Methods and evidence on volume-targeted ventilation in preterm infants

Nelson Claure1, Eduardo Bancalari

  • 1Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida 33101, USA.

Current Opinion in Pediatrics
|March 12, 2008
PubMed

Insights

Volume-targeted ventilation in premature infants shows potential for improved stability and faster weaning. However, current evidence does not fully confirm better long-term respiratory outcomes, requiring further research.

Area of Science:

  • Neonatal Medicine
  • Pediatric Respiratory Care
  • Critical Care

Background:

  • Volume-targeted ventilation (VTV) strategies are crucial for managing respiratory support in premature infants.
  • Various VTV modalities exist, some adapted from adult or older pediatric populations.

Purpose of the Study:

  • To describe VTV modalities used in preterm infants.
  • To review the clinical application and evidence for VTV's benefits in this population.

Main Methods:

  • Review of existing literature on VTV in preterm infants.
  • Analysis of physiologic studies and randomized controlled trials.

Main Results:

  • Physiologic studies suggest improved tidal volume stability and gas exchange with less ventilatory support.
  • Randomized trials show faster weaning and shorter mechanical ventilation duration, but not improved respiratory outcomes.

Conclusions:

  • The definitive benefits of VTV on respiratory outcomes in preterm infants are not yet confirmed.
  • Potential advantages may be method- and target-volume dependent, necessitating further investigation.
Abstract

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