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Methods and evidence on volume-targeted ventilation in preterm infants
Nelson Claure1, Eduardo Bancalari
1Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida 33101, USA.
Current Opinion in Pediatrics
|March 12, 2008
Summary
Volume-targeted ventilation in premature infants shows potential for improved stability and faster weaning. However, current evidence does not fully confirm better long-term respiratory outcomes, requiring further research.
Area of Science:
- Neonatal Medicine
- Pediatric Respiratory Care
- Critical Care
Background:
- Volume-targeted ventilation (VTV) strategies are crucial for managing respiratory support in premature infants.
- Various VTV modalities exist, some adapted from adult or older pediatric populations.
Purpose of the Study:
- To describe VTV modalities used in preterm infants.
- To review the clinical application and evidence for VTV's benefits in this population.
Main Methods:
- Review of existing literature on VTV in preterm infants.
- Analysis of physiologic studies and randomized controlled trials.
Main Results:
- Physiologic studies suggest improved tidal volume stability and gas exchange with less ventilatory support.
- Randomized trials show faster weaning and shorter mechanical ventilation duration, but not improved respiratory outcomes.
Conclusions:
- The definitive benefits of VTV on respiratory outcomes in preterm infants are not yet confirmed.
- Potential advantages may be method- and target-volume dependent, necessitating further investigation.
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