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Related Concept Videos

Blood Pressure Imbalances and Circulatory Shock01:24

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Related Experiment Video

Updated: Jul 6, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

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Published on: June 6, 2011

Surviving blood loss without fluid resuscitation.

Christian Shults1, Elizabeth A Sailhamer, Yongqing Li

  • 1Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.

The Journal of Trauma
|March 12, 2008
PubMed
Summary

Histone deacetylase inhibitors (HDACI) significantly improved survival in rats experiencing lethal hemorrhagic shock without fluid resuscitation. This finding offers a potential life-saving intervention for austere environments with limited medical supplies.

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Last Updated: Jul 6, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
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Published on: June 6, 2011

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Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs

Published on: May 21, 2019

Area of Science:

  • Biomedical research
  • Pharmacology
  • Trauma medicine

Background:

  • Massive blood loss poses a significant mortality risk, particularly in austere environments.
  • Effective interventions are needed to maintain viability during transport to definitive care.
  • Histone deacetylase inhibitors (HDACI) have previously demonstrated organ protection prior to hemorrhage.

Purpose of the Study:

  • To investigate the efficacy of post-hemorrhage HDACI administration in improving survival without fluid resuscitation.
  • To determine if HDACI can induce a pro-survival phenotype following lethal hemorrhagic shock.

Main Methods:

  • Seventy-two rats underwent 60% blood volume loss.
  • Animals received either valproic acid (VPA) or suberoylanilide hydroxamic acid (SAHA) post-hemorrhage.
  • Control groups included no hemorrhage, no resuscitation, saline resuscitation, and vehicle control.

Main Results:

  • Non-resuscitated shock resulted in 25% survival.
  • HDACI administration (VPA and SAHA) significantly increased survival to 75% and 83%, respectively (p < 0.05).
  • Survival rates for vehicle, sham, and saline groups were 40%, 100%, and 100%.

Conclusions:

  • Post-hemorrhage HDACI administration improves early survival in lethal hemorrhagic shock models, even without fluid resuscitation.
  • This strategy holds promise for battlefield or austere settings where fluid resuscitation is limited.
  • HDACI may represent a novel therapeutic approach for managing severe hemorrhage.