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Related Experiment Video

Updated: Jul 6, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Frontal-subcortical dementias.

Raphael M Bonelli¹, Jeffrey L Cummings

¹Department of Psychiatry, Graz Medical University, Graz, Austria.

The Neurologist

|March 12, 2008

Summary

This summary is machine-generated.

Frontal-subcortical dementias involve subcortical pathology and frontal dysfunction, presenting with memory loss, personality changes, and slowed thinking. These conditions may exist on a continuum with cortical dementias.

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Last Updated: Jul 6, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Area of Science:

Neuroscience
Neurology
Gerontology

Background:

Frontal-subcortical dementias (FSD) are a diverse group of disorders.
They are characterized by primary subcortical pathology and distinct neuropsychological deficits.

Purpose of the Study:

To define the characteristics and scope of frontal-subcortical dementias.
To explore the relationship between frontal-subcortical and cortical dementias.

Main Methods:

Review of existing literature and clinical data on various dementia types.
Analysis of anatomical and pathological findings in frontal-subcortical dementias.

Main Results:

FSD present with memory impairment, executive dysfunction, personality changes (apathy, depression), and bradyphrenia.
Conditions like Huntington's, Parkinson's disease dementia, and progressive supranuclear palsy are classic examples.
A continuum exists between FSD and cortical dementias, with significant overlap in pathology.

Conclusions:

The distinction between frontal-subcortical and cortical dementia may not be absolute.
These concepts remain useful for understanding dementia heterogeneity and disease progression.
Subcortical disorders share similarities that may distinguish them from Alzheimer's Disease.