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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Liver Regeneration

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Related Experiment Video

Updated: Jul 6, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Future perspectives for hepatocellular carcinoma.

W Y Lau1

  • 1Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong. josephlau@surgery.cuhk.edu.hk

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
|March 12, 2008
PubMed
Summary
This summary is machine-generated.

Hepatocellular carcinoma (HCC) management will evolve, with decreasing hepatitis B-related cases and increasing hepatitis C-related cases. Advances in screening, diagnosis, and therapy aim to improve patient outcomes and survival rates.

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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Area of Science:

  • Hepatology
  • Oncology
  • Public Health

Background:

  • Hepatocellular carcinoma (HCC) management encompasses five key areas: epidemiology, prevention, screening, diagnosis, and therapy.
  • Recent literature on HCC has been reviewed to forecast disease management trends over the next decade.

Purpose of the Study:

  • To predict future directions in hepatocellular carcinoma (HCC) management.
  • To anticipate developments in HCC epidemiology, prevention, screening, diagnosis, and therapy over the next ten years.

Main Methods:

  • Review of recent scientific papers and literature on hepatocellular carcinoma (HCC).
  • Forecasting and prediction of future trends in HCC management based on current data and research.

Main Results:

  • Hepatitis B-related HCC is predicted to decrease due to vaccination, while hepatitis C-related HCC is expected to rise.
  • Antiviral treatments and chemopreventive agents are expected to prevent HCC development.
  • Screening will focus on individuals who can afford it, with increased emphasis on tumor markers and advanced imaging (ultrasound, CT).

Conclusions:

  • Surgical outcomes for HCC will only improve with effective neoadjuvant/adjuvant therapy.
  • More unresectable HCC cases will become resectable through improved therapies, with increased use of liver transplantation.
  • Local ablative therapy may enhance survival quality but not overall survival compared to resection.