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Related Experiment Video

Updated: Jul 6, 2026

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

Published on: August 17, 2010

Surgically transplanted ovary simulating a hepatic metastasis.

F A Morello¹, E van Sonnenberg, B W Goodacre

¹Department of Radiology, Albany Medical Center, Albany, NY, USA.

HPB : the Official Journal of the International Hepato Pancreato Biliary Association

|March 12, 2008

Summary

Surgically repositioned ovaries can mimic hepatic metastases on CT scans, especially with limited patient history. Recognizing this surgical alteration is crucial for accurate diagnostic interpretation in cross-sectional imaging.

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Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice

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An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses

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Area of Science:

Radiology
Surgical Oncology
Abdominal Imaging

Background:

Cross-sectional imaging interpretation can be confounded by anatomical alterations from prior surgeries.
Diagnostic challenges are amplified when patient history or previous imaging studies are unavailable.

Purpose of the Study:

To highlight a case where a repositioned ovary mimicked a hepatic metastasis on computed tomography (CT).
To emphasize the importance of clinical history and prior imaging in preventing diagnostic errors in post-surgical patients.

Main Methods:

A case report of a 29-year-old woman treated for cervical carcinoma with radical hysterectomy.
One ovary was repositioned into the right paracolic gutter to avoid radiation fields.
Subsequent CT examinations were reviewed for interpretive challenges.

Main Results:

The repositioned ovary was misinterpreted as a hepatic metastasis on serial CT scans.
The obscure patient history contributed significantly to the diagnostic difficulty.

Conclusions:

Key diagnostic clues for differentiating surgical alterations from true pathology are presented.
Adequate patient history and access to previous radiological examinations are vital for accurate interpretation and avoiding misdiagnosis.