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Updated: Jul 6, 2026
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Organ Ischemia-Reperfusion Injury by Simulating Hemodynamic Changes in Rat Liver Transplant Model
Published on: March 6, 2021
Hyperbaric oxygen therapy and liver transplantation
Vijayaragavan Muralidharan1, Chris Christophi
1University of Melbourne Department of Surgery, Austin Hospital, Melbourne, Australia. muv@unimelb.edu.au
Summary
Hyperbaric oxygen (HBO) therapy may mitigate organ damage and rejection following liver transplantation. This review explores HBO
Area of Science:
- Transplantation immunology
- Organ preservation
- Hyperbaric medicine
Background:
- Liver transplantation is crucial for end-stage liver disease and primary liver malignancies.
- Donor organ availability limits liver transplantation.
- Marginal donor organs, split-liver, and living-related techniques increase donor pool but raise risks of organ dysfunction due to ischemia, preservation, and reperfusion injury (IPRI).
Purpose of the Study:
- To review the rationale for using hyperbaric oxygen (HBO) therapy in transplantation.
- To emphasize the role of HBO in mitigating IPRI and acute cellular rejection in liver transplantation.
Main Methods:
- Literature review of studies on hyperbaric oxygen therapy in transplantation.
- Focus on mechanisms of HBO in preventing ischemia, preservation, and reperfusion injury (IPRI).
Main Results:
- Studies suggest hyperbaric oxygen (HBO) therapy can positively influence ischemia, preservation, and reperfusion injury (IPRI).
- HBO therapy may reduce the incidence of consequential acute cellular rejection post-transplantation.
Conclusions:
- Hyperbaric oxygen (HBO) therapy presents a promising strategy to improve outcomes in liver transplantation.
- HBO's potential to reduce organ dysfunction and rejection warrants further investigation in clinical settings.
