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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Periodontal morphological microcirculation in oral lichen planus
Giuseppe Alessandro Scardina1, Antonino Cacioppo, Francesco Carini
1Department of Oral Science, University of Palermo, Italy. scardina@odonto.unipa.it
Summary
Videocapillaroscopy revealed significant vascular pattern differences in periodontal lichen planus (PLP). PLP patients exhibit increased capillary diameter and density, indicating heightened angiogenesis compared to healthy individuals.
Area of Science:
- Oral Medicine
- Dermatology
- Microcirculation Research
Background:
- Periodontal lichen planus (PLP) is an oral mucosal condition.
- Understanding its microcirculatory changes is crucial for diagnosis and treatment.
- Previous research has not fully elucidated the specific vascular alterations in PLP.
Purpose of the Study:
- To compare the microvascular patterns of periodontal mucosa between PLP patients and healthy controls.
- To identify specific videocapillaroscopic parameters that differ significantly between the two groups.
Main Methods:
- A comparative study involving 54 participants (27 PLP patients, 27 healthy controls).
- Videocapillaroscopy examination of periodontal mucosa (teeth 1.1 and 2.1).
- Analysis of capillary loop length, diameter, tortuosity, density, avascular areas, microhaemorrhages, and morphology, followed by statistical analysis.
Main Results:
- Statistically significant differences were observed in capillary density, loop length, and total diameter.
- PLP patients showed increased capillary diameter and density compared to controls.
- A notable increase in capillary density suggests significant angiogenic activity in PLP.
Conclusions:
- Videocapillaroscopy is effective in differentiating vascular patterns in PLP.
- Increased capillary diameter and density are characteristic microcirculatory features of PLP.
- The findings suggest active angiogenesis in periodontal lichen planus.
