Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liver fibrosis.

Karen Wallace1, Alastair D Burt, Matthew C Wright

  • 1Clinical and Laboratory Sciences, Institute of Cellular Medicine, Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

The Biochemical Journal
|March 13, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Alarming Consequences of Workforce Reductions at the FDA, EPA, NIH and CDC in the United States.

NAM journal·2026
Same author

Neurobehavioural Effects of the Methylimidazolium Ionic Liquid M8OI in Rats.

Journal of xenobiotics·2026
Same author

Head to head: should portal inflammation be part of grading necroinflammatory activity in metabolic dysfunction-associated steatotic liver disease?

Histopathology·2026
Same author

Investigating the mechanisms of indocyanine green tumour uptake in sarcoma cell lines and ex vivo human tissue.

The Journal of pathology·2025
Same author

The Alarming Consequences of Workforce Reductions at the FDA, EPA, NIH and CDC in the United States.

Toxicology·2025
Same author

The Alarming Consequences of Workforce Reductions at the FDA, EPA, NIH and CDC in the United States.

Environmental toxicology and pharmacology·2025
Same journal

Nanobodies against Plasmodium adhesins that block receptor engagement and malaria parasite invasion.

The Biochemical journal·2026
Same journal

Persistence without turnover: the RhoG G12E mutant highlights the role of nucleotide cycling in RhoG signaling.

The Biochemical journal·2026
Same journal

Alternative Splicing of Rice Chloroplastic CuZn Superoxide Dismutase, OsCSD2: Impact on expression and protein characteristics.

The Biochemical journal·2026
Same journal

Difference and similarity between the ubiquitous secretory pathway Ca2+-ATPases, SERCA2b, and SPCA1a.

The Biochemical journal·2026
Same journal

A molecular perspective on dimethylarginine dimethylaminohydrolases structure and function.

The Biochemical journal·2026
Same journal

Proteolytic coordination of the OXPHOS Life Cycle.

The Biochemical journal·2026
See all related articles

Liver damage triggers inflammation and fibrosis, a scarring process that can lead to liver failure. Understanding liver fibroblast origins and interactions is key to developing new therapies for chronic liver disease.

Area of Science:

  • Hepatology
  • Cell Biology
  • Immunology

Background:

  • Liver damage initiates an inflammatory response, activating mesenchymal cells for wound healing.
  • Chronic damage causes progressive fibrosis, altering liver structure and function, potentially leading to cirrhosis and liver failure.
  • Modulating liver fibrogenesis requires understanding the diverse origins and biology of liver fibroblast populations.

Purpose of the Study:

  • To investigate the heterogeneous origins and activation mechanisms of liver fibroblasts in fibrogenesis.
  • To explore the role of intercellular communication, including cytokine and chemokine profiles, in regulating fibrogenic fibroblast activity.
  • To identify potential therapeutic targets for chronic liver disease by understanding fibrogenesis regulation.

Main Methods:

Related Experiment Videos

  • Review of existing literature on liver injury, inflammation, and fibrosis.
  • Analysis of fibroblast heterogeneity, including origins from hepatic stellate cells, portal tracts, bone marrow, and epithelial-mesenchymal transition.
  • Examination of the influence of liver-resident leukocytes, such as macrophages, on fibroblast activity.

Main Results:

  • Liver fibroblasts originate from multiple sources, including hepatic stellate cells, portal tracts, bone marrow, and epithelial-mesenchymal transition.
  • Fibroblast activation and fibrogenic activity are influenced by inflammatory signals and cytokine/chemokine profiles from liver-resident immune cells.
  • Fibroblasts play a complex role in both tissue remodeling during wound healing and potentially in driving liver regeneration.

Conclusions:

  • Understanding the complex intercellular interactions governing liver fibrogenesis is crucial for developing effective therapies.
  • Targeting specific fibroblast populations or their signaling pathways may offer novel therapeutic strategies for chronic liver disease.
  • Further research into the multifaceted roles of liver fibroblasts is warranted given the increasing prevalence of chronic liver disease.