Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
Automated Microbial Diagnostics01:24

Automated Microbial Diagnostics

Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...
Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Valence-activated arsenic nanozyme enables cascade-amplified chemodynamic therapy for hepatocellular carcinoma.

International journal of pharmaceutics·2026
Same author

Coordination-based nanocomposite hydrogel promotes tissue regeneration under infection-compromised conditions.

Regenerative biomaterials·2026
Same author

The Advances in Novel Delivery Strategies for Hirudin Against Cardiovascular Diseases.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

A Biomimetic Macrophage-Membrane-Fused Liposomal System Loaded with GVs-HV Recombinant Plasmid for Targeted Anti-Atherosclerosis Therapy.

Pharmaceutics·2025
Same author

Correction: Chen et al. Neutrophil-Camouflaged Stealth Liposomes for Photothermal-Induced Tumor Immunotherapy Through Intratumoral Bacterial Activation. <i>Pharmaceutics</i> 2025, <i>17</i>, 614.

Pharmaceutics·2025
Same author

Research on hemorrhagic stroke detection enhanced by magnetic nanoparticle-based magnetic induction.

Physiological measurement·2025

Related Experiment Video

Updated: Jul 6, 2026

Custom-made Microdialysis Probe Design
05:38

Custom-made Microdialysis Probe Design

Published on: July 21, 2015

On-line microdialysis coupled to analytical systems.

Gui Jin1, Qiaoyuan Cheng, Jian Feng

  • 1Department of Pharmaceutics, Zhejiang Chinese Medical University, Hangzhou 310053, PR China.

Journal of Chromatographic Science
|March 13, 2008
PubMed
Summary

Online microdialysis (MD) analytical systems offer near real-time data for small, low-concentration samples. This review details advancements in coupled MD techniques like liquid chromatography and mass spectrometry.

More Related Videos

Dissolved Solute Sampling Across an Oxic-Anoxic Soil-Water Interface Using Microdialysis Profilers
11:43

Dissolved Solute Sampling Across an Oxic-Anoxic Soil-Water Interface Using Microdialysis Profilers

Published on: March 24, 2023

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats
08:47

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

Related Experiment Videos

Last Updated: Jul 6, 2026

Custom-made Microdialysis Probe Design
05:38

Custom-made Microdialysis Probe Design

Published on: July 21, 2015

Dissolved Solute Sampling Across an Oxic-Anoxic Soil-Water Interface Using Microdialysis Profilers
11:43

Dissolved Solute Sampling Across an Oxic-Anoxic Soil-Water Interface Using Microdialysis Profilers

Published on: March 24, 2023

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats
08:47

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

Area of Science:

  • Analytical Chemistry
  • Biomedical Engineering
  • Pharmacokinetics

Background:

  • In vivo interstitial fluid sampling via microdialysis (MD) is standard.
  • Small sample volumes and low analyte concentrations pose analytical challenges.
  • High-sensitivity analytical techniques are increasingly coupled with MD.

Purpose of the Study:

  • To review online microdialysis (MD)-analytical systems.
  • To highlight recent methodological advancements.
  • To discuss advantages, limitations, and adaptivity of these systems.

Main Methods:

  • Online MD coupled with liquid chromatography (LC).
  • Online MD coupled with capillary electrophoresis (CE).
  • Online MD coupled with mass spectrometry (MS).
  • Online MD coupled with biosensors.

Main Results:

  • Online systems provide near real-time analytical data.
  • Significant progress in methodologies for coupled MD techniques.
  • Comparative analysis of advantages, limitations, and adaptivity.

Conclusions:

  • Online MD-analytical systems are crucial for real-time monitoring.
  • Advancements enhance sensitivity and applicability of MD sampling.
  • These integrated systems are vital for pharmacokinetic and other in vivo studies.