Crystal structure of a full-length beta-catenin

Yi Xing1, Ken-Ichi Takemaru, Jing Liu

  • 1Department of Biological Structure, University of Washington School of Medicine, Seattle, WA 98195, USA.

Summary

Structural insights into beta-catenin reveal a novel alpha helix in its C-terminal domain. This finding redefines interactions with key partners, impacting cell adhesion and Wnt signaling pathways relevant to cancer.

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