Synthesis and study of antiviral and anti-radical properties of aminophenol derivatives
O Shadyro1, G Ksendzova, G Polozov
1Department of Chemistry of the Belarusian State University, Nezavisimosty Avenue 4, 220030 Minsk, Belarus. shadyro@open.by
Abstract:
A number of sterically-hindered o-aminophenol derivatives have been synthesized, and their antiviral activity in parallel with reactivity towards commonly encountered free-radical intermediates was investigated. Of the compounds tested, the highest activity in suppressing replication of Herpes simplex type l viruses was displayed by N-acyl and N-aryl derivatives of 4,6-di-tert-butyl-2-aminophenol, which were able to interact with organic free radicals and, at the same time, manifested low reactivity towards reactive oxygen species.
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