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Updated: Jul 6, 2026

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Published on: November 17, 2015

Functionalized solid lipid nanoparticles for transendothelial delivery.

A Jayagopal¹, E M Sussman, V P Shastri

¹Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, USA. ash..jayagopal@vanderbilt.edu

IEEE Transactions on Nanobioscience

|March 13, 2008

Summary

This summary is machine-generated.

Functionalized solid lipid nanoparticles (fSLN) with tunable surface chemistry were developed for enhanced drug delivery. These fSLN demonstrated effective transport across endothelial cells, showing potential for bioimaging and therapeutic applications.

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Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

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Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

Area of Science:

Nanotechnology
Biomedical Engineering
Materials Science

Background:

Solid lipid nanoparticles (SLN) are a promising drug delivery system.
Surface functionalization of nanoparticles is crucial for targeted delivery and cellular interaction.
Endothelial cell monolayers present a barrier to drug transport, necessitating strategies for enhanced translocation.

Purpose of the Study:

To synthesize and characterize functionalized solid lipid nanoparticles (fSLN).
To investigate the interaction of fSLN with endothelial cell monolayers.
To evaluate the transendothelial transport capabilities of fSLN for drug delivery and bioimaging.

Main Methods:

fSLN were prepared using a single-step phase-inversion process with surface modification by various macromolecules.
Particle size and surface charge were analyzed using dynamic light scattering and transmission electron microscopy.
Transendothelial transport and cellular localization were assessed using transwell assays and fluorescence microscopy.

Main Results:

Tunable size and surface functionality of fSLN were achieved.
fSLN with PSS-PLL-Hep functionalization translocated significant amounts of cargo (TRITC-BSA) within 4 hours.
Specific fSLN formulations showed distinct localization patterns (apical, paracellular, cytosolic) and cargo release (Coumarin 6).

Conclusions:

A rapid method for producing fSLN with diverse payloads and tunable surface chemistry was developed.
fSLN exhibit potential for internalization and translocation across intact endothelial cell monolayers.
These findings support the application of fSLN in drug delivery and bioimaging.