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Related Concept Videos

Chi-square Analysis02:46

Chi-square Analysis

The chi-square test is a statistical hypothesis test. It is used to check whether there is a significant difference between an expected value and an observed value. In the context of genetics, it enables us to either accept or reject a hypothesis, based on how much the observed values deviate from the expected values.
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

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Related Experiment Video

Updated: Jul 6, 2026

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases
05:02

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Published on: October 24, 2019

Searching MEDLINE via PubMed.

Frances A Delwiche1

  • 1Dana Medical Library, University of Vermont, Medical Education Center, Burlington, VT 05405, USA. frances.delwiche@uvm.edu

Clinical Laboratory Science : Journal of the American Society for Medical Technology
|March 14, 2008
PubMed
Summary

Learn efficient PubMed searching strategies to navigate the growing biomedical literature. This guide covers basic and advanced techniques, including MyNCBI, essential for clinical laboratory scientists.

Area of Science:

  • Biomedical Informatics
  • Information Science
  • Clinical Laboratory Science

Background:

  • The exponential growth of biomedical literature necessitates advanced information retrieval skills.
  • Indexing databases have become increasingly complex, challenging researchers and scientists.
  • Effective literature searching is crucial for staying current in clinical laboratory science.

Purpose of the Study:

  • To provide clinical laboratory scientists with essential skills for efficient biomedical literature searching.
  • To detail basic and advanced search strategies for the PubMed database.
  • To introduce users to specialized features within PubMed, such as MyNCBI.

Main Methods:

  • Description of fundamental search techniques in PubMed.

Related Experiment Videos

Last Updated: Jul 6, 2026

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases
05:02

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Published on: October 24, 2019

  • Explanation of advanced search functionalities and query construction.
  • Guidance on utilizing personalized features like MyNCBI for tailored results.

    • Main Results:

    • Users will gain proficiency in constructing effective search queries.
    • Understanding of how to leverage PubMed's advanced features for targeted literature retrieval.
    • Ability to manage and organize search results using tools like MyNCBI.

    Conclusions:

    • Mastering PubMed search strategies enhances the ability to efficiently access relevant biomedical information.
    • The described techniques are vital for clinical laboratory scientists to maintain expertise.
    • Utilizing specialized features like MyNCBI optimizes the literature review process.