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Updated: May 28, 2026
08:41
Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
Adiponectin and its role in cardiovascular diseases
Jerzy Bełtowski1, Anna Jamroz-Wiśniewska, Sylwia Widomska
1Department of Pathophysiology, Medical University, Lublin, Poland. Jerzy.beltowski@am.lublin.pl
Cardiovascular & Hematological Disorders Drug Targets
|March 14, 2008
Summary
Adiponectin, a beneficial adipokine, is lower in obesity and linked to metabolic syndrome. Increasing adiponectin levels may treat cardiovascular and metabolic diseases.
Area of Science:
- Endocrinology
- Metabolic Syndrome Research
- Cardiovascular Science
Background:
- Adipose tissue functions as an endocrine organ, secreting adipokines.
- Unlike many adipokines detrimental in obesity, adiponectin is reduced and offers protective benefits.
- Adiponectin influences insulin sensitivity, fatty acid oxidation, inflammation, and vascular function.
Purpose of the Study:
- To review the beneficial roles of adiponectin.
- To highlight the link between low adiponectin levels and metabolic/cardiovascular diseases.
- To discuss therapeutic strategies targeting adiponectin.
Main Methods:
- Review of studies on adipokines and adipose tissue.
- Analysis of adiponectin's effects on insulin sensitivity and vascular health.
- Examination of clinical data on adiponectin levels in disease states.
Main Results:
- Adiponectin exhibits beneficial effects, including enhanced insulin sensitivity and vasorelaxation.
- Adiponectin knockout mice display metabolic syndrome features.
- Lower plasma adiponectin is observed in hypertension and ischemic heart disease patients.
Conclusions:
- Adiponectin's unique protective role in metabolic and cardiovascular health is established.
- Therapeutic strategies to increase adiponectin levels show promise for treating metabolic and cardiovascular diseases.
- Thiazolidinediones are effective in raising adiponectin levels.
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