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Updated: Jul 6, 2026
11:34
Scattering And Absorption of Light in Planetary Regoliths
Published on: July 1, 2019
First-line randomized trials: revisiting the Ptolemaic universe
1Division of Medical Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA. michael.bookman@fccc.edu
Summary
Epithelial ovarian cancer initially responds well to platinum-based chemotherapy. However, new combination regimens have not yet proven superior to standard carboplatin and paclitaxel for improving long-term survival.
Area of Science:
- Gynecologic Oncology
- Medical Oncology
- Clinical Trials
Background:
- Epithelial ovarian cancer (EOC) is highly chemosensitive initially, with response rates over 80% to platinum-based therapy combined with surgery.
- Long-term survival is limited by tumor recurrence and acquired drug resistance.
- Standard treatment involves platinum and taxanes, but novel combinations are being investigated.
Purpose of the Study:
- To evaluate the efficacy of new platinum-based doublet and triplet chemotherapy combinations in epithelial ovarian cancer.
- To improve long-term outcomes by developing novel platinum-based treatment strategies.
- To assess the role of diverse cytotoxic agents in combination therapy for EOC.
Main Methods:
- International collaborative phase III trials involving over 10,000 randomized women.
- Evaluation of various cytotoxic agents (docetaxel, topotecan, gemcitabine, PEG-liposomal doxorubicin) in combination regimens.
- Comparison of novel combinations against standard carboplatin and paclitaxel.
Main Results:
- Preliminary data from several phase III trials have been reported.
- Currently, no new two- or three-drug combination has demonstrated superiority over the standard carboplatin and paclitaxel regimen.
- Final data from ongoing trials are pending.
Conclusions:
- Carboplatin with paclitaxel remains the standard of care for epithelial ovarian cancer.
- Despite extensive research, current evidence does not support adopting new combination regimens.
- Future clinical trials must consider advancements in molecular-targeted therapy.
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