Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Autologous stem cell transplantation in diffuse scleroderma: impact on hand structure and function.

H Englert¹, S Kirkham, J Moore

¹Department of Rheumatology, Westmead Hospital, Sydney, New South Wales, Australia. helenen@westgate.wh.usyd.edu.au

Internal Medicine Journal

|March 14, 2008

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Chronic Angioedema Registry (CARE): Rationale, Methods and Implementation.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2024

Same author

Arerugi = [Allergy]·2023

Same author

Arerugi = [Allergy]·2023

Same author

Arerugi = [Allergy]·2023

Same author

Effect of a 6-Month Controlled Lifestyle Intervention on Common Carotid Intima-Media Thickness.

The journal of nutrition, health & aging·2021

Same author

<sup>99m</sup>Tc-labelled glucosamine in the assessment of systemic sclerosis inflammatory lung disease: a novel inexpensive investigative tool with predictive value.

Annals of nuclear medicine·2021

Same journal

The paradox of peer review: protecting science or policing thought?

Internal medicine journal·2026

Same journal

Immune-related pancytopenia in pregnancy.

Internal medicine journal·2026

Same journal

Crossover effect: causal machine learning reveals opposing mortality responses to mean arterial pressure targets among phenotypically distinct hypertensive patients with septic shock.

Internal medicine journal·2026

Same journal

Clinicopathological findings, correlations and outcomes in patients with renal disease and living with antiretroviral-treated human immunodeficiency virus infection.

Internal medicine journal·2026

Same journal

Approach to thyroid disorders associated with immune checkpoint inhibitors and tyrosine kinase inhibitors.

Internal medicine journal·2026

Same journal

A scoping review of specialist hypertension clinics.

Internal medicine journal·2026

See all related articles

Autologous stem cell transplantation (ASCT) improved scleroderma finger clawing and hand function within 12 months. ASCT resolved tenosynovitis, with functional gains most significant in employment and self-care.

Area of Science:

Rheumatology
Immunology
Regenerative Medicine

Background:

Scleroderma causes significant hand deformities, including finger clawing.
Autologous stem cell transplantation (ASCT) is an emerging treatment for systemic sclerosis.

Purpose of the Study:

To evaluate the structural and functional impact of ASCT on scleroderma-related finger clawing.
To assess changes in tenosynovitis, skin scores, and hand function post-ASCT.

Main Methods:

Photographic assessment of hands from five scleroderma patients before and after ASCT.
Standardized questionnaire for functional assessments.
Measurement of hand dimensions and finger abduction.

Main Results:

Related Experiment Videos

ASCT resolved synovitis and tenosynovitis in most patients.
Modified Rodnan hand skin scores decreased post-ASCT.
Significant improvements in hand function were observed, particularly in employment and self-care.
Finger abduction measures proved more sensitive to clawing than hand length.

Conclusions:

ASCT effectively improves hand scleroderma, including refractory tenosynovitis, over 12 months.
Hand function, especially related to daily activities and employment, significantly improves post-ASCT.
Finger abduction is a key indicator for assessing scleroderma-related finger clawing.