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Updated: Jul 6, 2026
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Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
Mice with pulmonary tuberculosis treated with Mycobacterium vaccae develop strikingly enhanced recall gamma
Elisabeth Rodríguez-Güell1, Gemma Agustí, Mercè Corominas
1Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Catalonia, Spain.
Clinical and Vaccine Immunology : CVI
|March 14, 2008
Abstract:
Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma interferon in splenocytes from both non-TB and TB M. vaccae-treated mice.
