Related Experiment Video
Updated: Jul 6, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
Published on: October 31, 2025
Widespread maculopapular rash due to intramuscular interferon beta-1a during the treatment of multiple sclerosis
G Serarslan1, Ee Okuyucu, Im Melek
1Department of Dermatology, Mustafa Kemal University, Faculty of Medicine, Antakya, Turkey. gserarslan@hotmail.com
Abstract:
We describe a 41-year-old woman with multiple sclerosis, who presented erythematous maculopapular rash on the trunk and extremities after the second injection of interferon beta-1a. Histopathologic examination of the lesion revealed lymphocytic exocytosis and perivascular lymphocytic infiltrate in the dermis. Oral antihistamine and topical corticosteroid was started. After improvement of the lesions, the third injection was performed. However, the same reaction occurred. A prick test, which was performed 6 weeks after the eruption, also revealed positive reaction. Although injection-site reactions have been observed with interferon beta-1a, to our knowledge there have been no previous reports of interferon beta-1a-induced widespread cutaneous reaction.
Related Concept Videos
Inhibitors of Viral Protein Synthesis
Multiple Sclerosis l: Introduction
Rocky Mountain Spotted Fever
Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Hypersensitivity Reactions: Immune-Complex Reactions