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Is the use of letrozole to induce ovulation teratogenic?
Canadian Family Physician Medecin De Famille Canadien
|March 14, 2008
Abstract
Question:
A patient of mine has been prescribed letrozole to induce ovulation; however, a recent release from the Food and Drug Administration contraindicates the use of letrozole in premenopausal women owing to teratogenicity. Does the use of letrozole increase the risk of a child being born with a birth defect?
Answer:
The use of letrozole to induce ovulation has not been associated with an increased risk of a child being born with a birth defect; in contrast, the use of clomiphene citrate in pregnancy is associated with intrauterine growth restriction.
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