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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...

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Vitamin D(3) in fat tissue.

Miriam Blum1, Gregory Dolnikowski, Elias Seyoum

  • 1Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA, 02111, USA.

Endocrine
|March 14, 2008
PubMed
Summary
This summary is machine-generated.

This study measured vitamin D(3) in obese adults' fat tissue and serum using LC/MS. Fat tissue vitamin D(3) levels correlated positively with serum levels, confirming fat as a vitamin D storage site.

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Biochemistry

Background:

  • Limited literature exists on vitamin D content in adipose tissue.
  • Obesity is often associated with suboptimal vitamin D status.
  • Adipose tissue is hypothesized to be a storage site for vitamin D.

Purpose of the Study:

  • To quantify vitamin D(3) concentrations in serum and subcutaneous fat of obese adults.
  • To investigate the correlation between vitamin D(3) levels in fat tissue and serum.
  • To assess the feasibility of measuring vitamin D(3) in fat tissue using LC/MS.

Main Methods:

  • A pilot, cross-sectional study involving 17 obese adults undergoing gastric bypass surgery.
  • Measurement of vitamin D(3) concentrations in serum and subcutaneous fat samples.
  • Utilized a novel liquid chromatography-mass spectrometry (LC/MS) method for precise quantification.

Main Results:

  • Mean vitamin D(3) concentration in subcutaneous fat was 102.8 ± 42.0 nmol/kg.
  • Mean serum vitamin D(3) concentration was 7.78 ± 3.99 nmol/l.
  • A significant positive correlation (r = 0.68, P = 0.003) was observed between fat tissue and serum vitamin D(3) levels.

Conclusions:

  • Vitamin D(3) is measurable in the fat tissue of obese individuals with suboptimal vitamin D status using LC/MS.
  • The positive correlation supports the role of adipose tissue as a reservoir for vitamin D.
  • This study provides novel insights into vitamin D distribution in obese populations.