Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Malaria

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

Antiprotozoal Agents

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

Pharmacogenomics: Identification of New Drug Targets

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

Histone Modification

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

Histone Modification

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

Anthelminthic Agents

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Artemisia annua L. essential oil-loaded chitosan nanoparticles: synthesis, characterization, in-vitro release kinetics, and acetylcholinesterase inhibition as a mode of action against plant-parasitic nematodes.

International journal of biological macromolecules·2025

Same author

Phytochemical Insights and Acetylcholinesterase-Targeted Nematicidal Activity of Digitalis purpurea L. Extracts in Biological Control of Meloidogyne incognita.

Chemistry & biodiversity·2025

Same author

Medicinal plants of the family Caryophyllaceae: a review of ethno-medicinal uses and pharmacological properties.

Integrative medicine research·2017

Same author

Seroprevalence of transfusion-transmissible infections among replacement and voluntary blood donors in a tertiary care hospital.

Indian journal of sexually transmitted diseases and AIDS·2017

Same author

A Retrospective Analysis of Apheresis Donor Deferral and Adverse Reactions at a Tertiary Care Centre in India.

Journal of clinical and diagnostic research : JCDR·2017

Same author

Synthesis, characterization and in vitro anticancer activity of C-5 curcumin analogues with potential to inhibit TNF-α-induced NF-κB activation.

BioMed research international·2014

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

Published on: January 16, 2015

Histone as future drug target for malaria.

D S Rawat¹, V Lumb, Y D Sharma

¹Division of Biochemistry & Biotechnology, National Institute of Communicable Diseases, Delhi.

The Journal of Communicable Diseases

|March 15, 2008

Summary

Malaria remains a significant global health threat. Targeting histone proteins and epigenetic modifications offers a promising new avenue for developing effective and affordable malaria drugs.

More Related Videos

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases

Published on: November 22, 2024

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

Related Experiment Videos

Last Updated: Jul 6, 2026

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

Published on: January 16, 2015

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases

Published on: November 22, 2024

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

Area of Science:

Genetics
Parasitology
Pharmacology

Background:

Malaria affects approximately 100 countries, causing millions of deaths annually.
Genomic insights into Plasmodium, Anopheles, and Homo sapiens advance understanding of malaria.
Technological progress aids in identifying new drug and vaccine targets.

Purpose of the Study:

To highlight the need for potent and affordable antimalarial drugs.
To explore histone proteins and their post-translational modifications as potential therapeutic targets.
To investigate chromatin regulators and upstream pathways for drug development.

Main Methods:

Review of current knowledge on malaria's impact and genomic research.
Analysis of histone protein functions in DNA packaging, replication, and gene expression.
Exploration of epigenetic mechanisms, specifically post-translational modifications of histones.

Main Results:

Histones play crucial roles in chromatin structure and genome regulation.
Post-translational modifications of histones act as epigenetic codes influencing gene function.
Chromatin regulators present viable targets for antimalarial drug discovery.

Conclusions:

Developing new antimalarial drugs is critical due to ongoing malaria burden.
Histone modifications offer a novel therapeutic strategy for malaria treatment.
Targeting chromatin regulators holds promise for future antimalarial therapies.