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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
05:37

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

First evidence of a functional interaction between DNA quadruplexes and poly(ADP-ribose) polymerase-1

V A Soldatenkov, A A Vetcher, T Duka

    ACS Chemical Biology
    |March 15, 2008
    PubMed
    Summary

    Human poly(ADP-ribose) polymerase-1 (hPARP-1) binds DNA quadruplexes, activating its enzymatic function. This discovery offers insights into transcription regulation and telomere protection mechanisms.

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