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[Multicentric and localized tineas in immunocompromised patients]
Beatriz García de Acevedo1, Antonio Villa, Francisca Hernández-Hernández
1Departamento de Dermatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
Revista Iberoamericana De Micologia
|March 15, 2008
Summary
Multifocal tinea infections in immunocompromised patients are linked to female gender and immunosuppressive drugs. A weakened cellular immune response may explain these widespread fungal infections.
Area of Science:
- Dermatology
- Mycology
- Immunology
Context:
- Multifocal tinea infections present atypically in immunocompromised individuals.
- Risk factors for widespread tinea infections in immunocompromised patients are not well-established.
- This study investigates risk factors, immune response, and causative agents of multicentric tinea.
Purpose:
- Identify risk factors associated with multicentric tinea in immunocompromised patients.
- Evaluate immune response using trichophytin and candidin skin tests.
- Determine the etiological agents and serum interleukin levels in these patients.
Summary:
- Female gender and treatments with prednisone, azathioprine, and cyclophosphamide were associated with multicentric tinea.
- Trichophytin skin tests were negative in disseminated tinea cases, suggesting a cellular immune defect.
- Trichophyton rubrum was the most common fungal species identified.
Impact:
- Findings suggest a cellular immune response defect contributes to extensive tinea infections in immunocompromised individuals.
- Identifies specific risk factors, aiding in early detection and management of widespread tinea.
- Contributes to understanding fungal infections in immunocompromised populations.
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