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Related Experiment Videos

Using computational fluid dynamics to characterize and improve bioreactor performance.

William J Kelly1

  • 1Department of Chemical Engineering, Villanova University, 800 Lancaster Avenue, Villanova, PA 19085, USA. william.j.kelly@villanova.edu

Biotechnology and Applied Biochemistry
|March 15, 2008
PubMed
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Computational fluid dynamics (CFD) modeling is crucial for bioprocessing. This review highlights CFD

Area of Science:

  • Biochemical Engineering
  • Biomedical Engineering
  • Bioprocess Engineering

Background:

  • Computational fluid dynamics (CFD) has been applied to model single-phase flow in upstream bioprocessing.
  • Actual bioprocessing involves multi-phase systems, including cells, liquid, and gas bubbles.
  • Previous CFD models often simplified these complex, multi-phase interactions.

Purpose of the Study:

  • To review the application of CFD in modeling bioreactor performance.
  • To emphasize methods for handling multi-phase flow in CFD simulations.
  • To cover CFD studies in biochemical and biomedical literature.

Main Methods:

  • Literature review of CFD applications in bioreactor modeling.
  • Analysis of studies focusing on single-phase and multi-phase flow.

Related Experiment Videos

  • Summary of techniques for modeling momentum and mass transfer between phases.

    • Main Results:

    • CFD is increasingly used to model complex bioprocessing environments.
    • Multi-phase flow modeling, including cells and gas bubbles, is a key development.
    • Studies demonstrate CFD's utility in understanding bioreactor hydrodynamics and mass transfer.

    Conclusions:

    • CFD is a valuable tool for optimizing bioreactor design and operation.
    • Advanced CFD models are essential for accurately simulating multi-phase bioprocessing.
    • Further research in multi-phase CFD will enhance bioprocess efficiency and scalability.